Table 1 Summary of the functional features of KRAB-containing zinc-finger repressor proteins
Subfamily | Protein | Species | Chromosomal localization | Number of zinc fingers | Expression pattern | Proposed function |
|---|---|---|---|---|---|---|
A + B subfamily | HKr18 | Human | 19 | 20 | Ubiquitous | Repressor or RNA pol II |
HKr19 | Human | 7 | 11 | Testis | Cell differentiation | |
KID-1 | Human | 5q35.3 | 13 | Ubiquitous | Nucleolar integrity | |
Kid2 | Mouse | 11 | 13 | Embryonic brain, kidney, gut and lung | Mouse development | |
Kid3 | Mouse | 11 | 11 | Embryonic (E16.5) kidney, gut, lung and heart | Kidney development | |
KOX1 | Human | 12q24.33 | 9 | Ubiquitous | Repressor of RNA pol I, II, and II promoters | |
KRAZ1 | Mouse | 17 | 15 | Ubiquitous | Repressor or RNA pol II | |
KRAZ2 | Mouse | 5 | 9 | Ubiquitous | Repressor or RNA pol II | |
KS1 | Rat | 10 | Ubiquitous | Tumor suppressor | ||
KZF-1 | Rat | 6 | 9 | Testis | Spermatogenesis | |
RbaK | Human | 7 | 16 | Ubiquitous | Cell cycle arrest | |
RITA | Human | 9q13 | 12 | Ubiquitous | Thyroid carcinoma | |
ZBRK1 | Human | 19q13.41 | 8 | Skeletal muscle | Interaction with Brca1 | |
ZF5128 | Human | 19 | 9 | Ubiquitous | T cell activation | |
ZNF41 | Human | Xp11.2 | 18 | Ubiquitous | Flanking a translocation breakpoint in synovial sarcoma | |
ZNF43 | Human | 19p13.1-p12 | 22 | T cell, B cell, and Ewing cells | Differentiation and growth arrest in Ewing cells | |
ZNF85 | Human | 19p13.1-p12 | 15 | Ubiquitous | Repressor RNA pol II | |
ZNF91 | Human | 19p12 | 27 | Seminoma and lymphoid cells | Repression of the human Fc gamma RIIB gene | |
ZNF133 | Human | 20p11.23 | 15 | Ubiquitous | Repressor RNA pol II | |
ZNF140 | Human | 12q24 | 9 | Lymphoid cells | Repression of the human Fc gamma RIIB gene | |
ZNF141 | Human | 4p16.3 | 10 | Ubiquitous | Candidate for the Wolf-Hirschhorn syndrome | |
ZNF157 | Human | Xp11.2 | 12 | Blood vessels | Potential hotspot for neurogenetic disorders | |
A subfamily | HZF12 | Human | 19 | 9 | Ubiquitous | Repressor of RNA pol II |
MZF31 | Mouse | 2 | 9 | Ubiquitous | Repressor of RNA pol II | |
pMLZ-8 | Mouse | 4 | 15 | Ubiquitous | Repressor of RNA pol II | |
ZK1 | Human | 19p13.2 | 15 | Hematopoietic and various cancer cells | Radiation-induced apoptotic cell death | |
ZNF136 | Human | 19p13.1-p12 | 13 | Ubiquitous | Weak repressor of RNA pol II | |
A + b subfamily | HZF4 | Human | 19p13.32 | 18 | Ubiquitous | Repressor of RNA pol II |
Zfp93 | Human | 19p13.1-p12 | 15 | Ubiquitous | Repressor of RNA pol II | |
rKr2 | Rat | 1 | 19 | Central nervous system and testis | Maturation of neurons and oligodendrocyte | |
ZNF45 | Human | 19p13.2 | 11 | Ubiquitous | Potential hotspot for malignant disorders | |
ZNF155 | Human | 19q13.2 | 11 | Ubiquitous | Repressor of RNA pol II | |
ZNF221 | Human | 19q13.2 | 15 | Ubiquitous | Repressor of RNA pol II | |
ZNF222 | Human | 19 | 7 | Ubiquitous | Repressor of RNA pol II | |
ZNF224 | Human | 19 | 16 | Ubiquitous | Repressor of RNA pol II | |
ZNF225 | Human | 19 | 17 | Ubiquitous | Repressor of RNA pol II | |
ZNF226 | Human | 19 | 17 | Ubiquitous | Repressor of RNA pol II | |
SCAN subfamily | FPM315 | Human | 16p13.3 | 9 | Ubiquitous | Represses the Col11a2 promoter |
SKAT2 | Mouse | 11 | 14 | Brain, kidney and hematopoietic cells | Regulation of cytokine in T cells | |
Skz1 | Mouse | 13 | 7 | Ubiquitous | Repressor of RNA pol II | |
ZFP95 | Human | 7 | 13 | Ubiquitous | Repressor of RNA pol II | |
ZNF197 | Human | 3p21. | 20 | Ubiquitous | Repressor of RNA pol II | |
ZNF202 | Human | 11q23.3 | 8 | Ubiquitous | Energy metabolism | |
ZNF274 | Human | 19q | 7 | Ubiquitous | Repressor of RNA pol II |