Figure 1
A human artificial minichromosome (or HAC) carrying a neocentromere. (a) Identification by fluorescent in situ hybridization (FISH) of the HAC (arrowhead) using a DNA probe for chromosome 10q25. Positive signals at the 10q25 regions of the two normal human chromosomes 10 are also visible. (b) Staining of the same nucleus with DAPI, which recognizes DNA, showing the relative size of the HAC compared with the other human chromosomes. Figure courtesy of Andy Choo.