Figure 2

Schematic representation of the domain assignments to hypothetical protein kinases encoded in the human genome. Protein kinase domains are shown in red. The other domains are labeled as follows: ARMB, ARM repeats of β-catenin-like proteins; ARMH, HEAT-related ARM-repeats; eH, homologous regions found in proteins of eukaryotes (C. elegans, D. melanogaster, Arabidopsis thaliana); HH, homologous region found in human proteins; MH, homologous regions found in proteins of mammals (mouse and human); PDZ, a conserved domain in PSD95, DLG and ZO-1; PrH, homologous regions found in proteins of primates (Macaca species and human); TM, transmembrane region. (a) function unknown (ENSP207880); (b) function unknown (ENSP252105); (c) function unknown (gi13652558; homologs have been found only in eukaryotes); (d) function unknown (ENSP250481; homologs have been found only in mouse); (e) function unknown (ENSP234334); (f) function unknown (ENSP232788); (g) function unknown (ENSP188359); (h) predicted BMP2-inducible kinase (ENSP251485); (i) protein kinase involved in embryonic development (ENSP250887); (j) protein kinase associated with the dystrophy complex (ENSP251197); (k) protein kinase similar to mouse apoptosis-associated kinase (ENSP251707); (l) protein kinase of unknown function (ENSP244847).