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Table 2 Receptor subgroups derived from a combination of neighbor-joining and BLASTP results

From: Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands

A1

A2

A3

A4

A5

A6

A7

A8

A9

A10

A11

C3X1

ADMR

AG22

GPR7

GALR

FF1R

BRS3

C3AR

GPR72

FSHR

GPR40

CKR1

BONZO

AG2R

GPR8

GALS

FF2R

ET1R

C5AR

GPR73

GPR48

GPR41

CKR2

CCR11

AG2S

OPRD

GALT

GASR

ETBR

C5L2

(GPR75)

GPR49

GPR42

CKR3

CCR3

APJ

OPRK

GPR54

(GPR)

ETBR-LP2

CML1

GPRA

LSHR

GPR43

CKR4

CCR4

BRB1

OPRM

GPRO

GPR103

GHSR

FML1

GPRJ

TSHR

GPR80

CKR5

CCR5

BRB2

OPRX

P2Y7

(GPRM)

GPR37

FML2

ML1A

 

GPR81

CKR8

CKR6

GPR25

SSR1

SALPR

GRHR

GPR38

FMLR

ML1B

 

GPR82

CKRX

CKR7

GPRF

SSR2

UR2R

OX1R

GPR39

GPR1

ML1X

 

GPR91

CXC1

CKR9

 

SSR3

 

OX2R

GRPR

GPR44

NK1R

 

GPRV

(TM7SF1)

CKRA

 

SSR4

 

OXYR

NMBR

GPRW

NK2R

 

HM74

 

CML2

 

SSR5

 

V1AR

NMU1R

(MAS)

NK3R

 

P2UR

 

(DUFF)

   

V1BR

NMU2R

(MRG)

NK4R

 

P2Y11

 

IL8A

   

V2R

NTR1

 

NY1R

 

P2Y4

 

IL8B

    

NTR2

 

NY2R

 

P2Y6

 

RDC1

    

TRFR

 

NY4R

 

P2YR

        

NY5R

  

A12

A13

A14

A15

A16

A17

A18

A19

 

B

C

GPR34

ACTR

PD2R

EBI2

OPSB

5H2A

AA1R

5H1A

 

BAI1

CASR

GPR86

CB1R

PE21

G2A

OPSD

5H2B

AA2A

5H1B

 

BAI2

GBR1

GPR87

CB2R

PE22

GPR35

OPSG

5H2C

AA2B

5H1D

 

BAI3

GBR2

H963

EDG1

PE23

GPR4

OPSR

5H6

AA3R

5H1E

 

CALR

GPRC5B

KI01

EDG2

PE24

GPR55

OPSX

A1AA

ACM1

5H1F

 

CD97

GPRC5C

P2Y12

EDG3

PF2R

GPR65

RGR

A1AB

ACM2

5H5A

 

CGRR

GPRC5D

PAFR

EDG4

PI2R

GPR68

 

A1AD

ACM3

5H7

 

CRF1

MGR1

 

EDG5

TA2R

GPR92

 

A2AA

ACM4

  

CRF2

MGR2

 

EDG6

 

GPRH

 

A2AB

ACM5

  

EMR1

MGR3

 

EDG7

 

GPRI

 

A2AC

GPR101

  

EMR2

MGR4

 

EDG8

 

GPRK

 

A2AD

GPR27

  

EMR3

MGR5

 

GPR3

 

P2Y10

 

B1AR

GPR52

  

GIPR

MGR6

 

GPR6

 

P2Y5

 

B2AR

GPR61

  

GLPR

MGR7

 

GPRC

 

P2Y9

 

B3AR

GPR62

  

GLR

MGR8

 

MC3R

 

PAR2

 

D2DR

GPR63

  

GPL2

 
 

MC4R

 

PAR3

 

D3DR

GPR78

  

GPR56

 
 

MC5R

 

THRR

 

D4DR

GPR84

  

GRFR

 
 

MSHR

   

DADR

GPR85

  

PACR

 
     

DBDR

(GPR88)

  

PTR2

 
     

GPR102

GPRL

  

PTRR

 
     

GPR57

HH1R

  

SCRC

 
     

GPR58

PSP24

  

VIPR

 
     

HH2R

RE2

  

VIPS

 
     

PNR

SREB3

    
  1. Very distantly related receptors that are possibly not phylogenetically related are shown in brackets. Orphan receptors are shown in bold.