Figure 7From: Both subtelomeric regions are required and sufficient for specific DNA fragmentation during macronuclear development in Stylonychia lemnaeModel for DNA processing during macronuclear development in hypotrichous ciliates. Inverted repeats acting as cis-acting DNA sequences required for DNA processing are localized in both subtelomeric regions but not necessarily at similar positions. By interaction of these sequences, a loop-like structure is formed, which is then resolved on its base by a specific nuclease. This implies that a precise cut is made only at the 3' end, the 5' end has to be filled in by a so far unknown proofreading mechanism. Telomeric sequences are then added de novo.Back to article page